Hiroaki Kaku, PhD

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Research Assistant Professor, Department of Investigative Medicine

Primary Address
Office
Western Michigan University Homer Stryker M.D. School of Medicine
1000 Oakland Drive
Kalamazoo, MI, United States 49008

Publications

Kaku H., Ludlow A.V., Gutknecht M.F., Rothstein T.L., Fas Apoptosis Inhibitory Molecule Blocks and Dissolves Pathological Amyloid-β Species, Frontiers in Molecular Neuroscience, 2021-12-14 00:00:00. (Journal). Published, 12/14/2021.
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Kaku H., Rothstein T.L., FAIM Is a Non-redundant Defender of Cellular Viability in the Face of Heat and Oxidative Stress and Interferes With Accumulation of Stress-Induced Protein Aggregates, Frontiers in Molecular Biosciences, 2020-02-27 00:00:00. (Journal). Published, 02/27/2020.
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Kaku H., Ludlow A.V., Gutknecht M.F., Rothstein T.L., FAIM Opposes Aggregation of Mutant SOD1 That Typifies Some Forms of Familial Amyotrophic Lateral Sclerosis, Frontiers in Neuroscience, 2020-02-21 00:00:00. (Journal). Published, 02/21/2020.
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Kaku H., Holodick N., Tumang J., Rothstein T., CD25<sup>+</sup> B-1a cells express Aicda, Frontiers in Immunology, 2017-06-20 00:00:00. (Journal). Published, 06/20/2017.
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Kaku H., Cheng K.F., Al-Abed Y., Rothstein T.L., A novel mechanism of B cell-mediated immune suppression through CD73 expression and adenosine production, Journal of Immunology, 2014-12-15 00:00:00. (Journal). Published, 12/15/2014.
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Rothstein T., Griffin D., Holodick N., Quach T., Kaku H., Human B-1 cells take the stage, Annals of the New York Academy of Sciences, 2013-05-01 00:00:00. (Book Series). Published, 05/2013.
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Tumang J., Holodick N., Vizconde T., Kaku H., Francés R., Rothstein T., A CD25<sup>-</sup> positive population of activated B1 cells expresses LIFR and responds to LIF, Frontiers in Immunology, 2011-01-01 00:00:00. (Journal). Published, 2011.
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Kaku H., Rothstein T.L., Fas apoptosis inhibitory molecule enhances CD40 signaling in B cells and augments the plasma cell compartment (Journal of Immunology (2009) 183, (1667-1674)), Journal of Immunology, 2010-07-01 00:00:00. (Journal). Published, 07/01/2010.
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Kaku H., Rothstein T., Octamer binding protein 2 (Oct2) regulates PD-L2 gene expression in B-1 cells through lineage-specific activity of a unique, intronic promoter, Genes and Immunity, 2010-01-01 00:00:00. (Journal). Published, 01/2010.
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Kaku H., Rothstein T., Fas apoptosis inhibitory molecule expression in B cells is regulated through IRF4 in a feed-forward mechanism, Journal of Immunology, 2009-11-01 00:00:00. (Journal). Published, 11/01/2009.
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Kaku H., Rothstein T., Fas apoptosis inhibitory molecule enhances CD40 signaling in B cells and augments the plasma cell compartment, Journal of Immunology, 2009-08-01 00:00:00. (Journal). Published, 08/01/2009.
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Hara-Yokoyama M., Kimura T., Kaku H., Wakiyama M., Kaitsu Y., Inoue M., Kusano S., Shirouzu M., Yokoyama S., Katada T., Hirabayashi Y., Takatsu K., Yanagishita M., Alteration of enzymatic properties of cell-surface antigen CD38 by agonistic anti-CD38 antibodies that prolong B cell survival and induce activation, International Immunopharmacology, 2008-01-01 00:00:00. (Journal). Published, 01/2008.
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Francés R., Tumang J., Kaku H., Gurdak S., Rothstein T., B-1 cells express transgelin 2: Unexpected lymphocyte expression of a smooth muscle protein identified by proteomic analysis of peritoneal B-1 cells, Molecular Immunology, 2006-05-01 00:00:00. (Journal). Published, 05/2006.
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Yokoyama M., Kimura T., Tsuchida S., Kaku H., Takatsu K., Hirabayashi Y., Yanagishita M., Roles of membrane domains in the signaling pathway for B cell survival, Sphingolipid Biology, 2006-01-01 00:00:00. (Book). Published, 2006.
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Kaku H., Horikawa K., Obata Y., Kato I., Okamoto H., Sakaguchi N., Gerondakis S., Takatsu K., NF-κB is required for CD38-mediated induction of C<inf>γ</inf>1 germline transcripts in murine B lymphocytes, International Immunology, 2002-09-01 00:00:00. (Journal). Published, 09/2002.
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Horikawa K., Kaku H., Nakajima H., Davey H., Henninghausen L., Iwamoto I., Yasue T., Kariyone A., Takatsu K., Essential role of stat5 for IL-5-dependent IgH switch recombination in mouse B cells, Journal of Immunology, 2001-11-01 00:00:00. (Journal). Published, 11/01/2001.
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