Nichol E Holodick, PhD

Nichol_Holodick.jpg
  • Assistant Professor, Department of Biomedical Sciences
    • Primary Address
    • Business
    • 1000 Oakland Drive
    • Kalamazoo, MI, United States 49008

Publications

Publications

  • Aziz M, Ode Y, Zhou M, Ochani M, Holodick NE, Rothstein TL, Wang P, B-1a cells protect mice from sepsis-induced acute lung injury., Molecular medicine (Cambridge, Mass.), 2018-05-29 00:00:00. (Journal Article). E-published, 05/29/2018.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=30134811
  • Hernandez A., Holodick N., Editorial: Natural antibodies in health and disease, Frontiers in Immunology, 2017-12-13 00:00:00. (Journal). Published, 12/13/2017.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=900000079
  • Holodick N., Rodríguez-Zhurbenko N., Hernández A., Defining natural antibodies, Frontiers in Immunology, 2017-07-26 00:00:00. (Journal). Published, 07/26/2017.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=900000080
  • Aziz M, Holodick NE, Rothstein TL, Wang P, Aziz M., Holodick N., Rothstein T., Wang P., B-1a Cells Protect Mice from Sepsis: Critical Role of CREB., Journal of immunology (Baltimore, Md. : 1950), 2017-07-15 00:00:00. (Journal Article , Journal). Published, 07/15/2017.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=28630091
  • Kaku H., Holodick N., Tumang J., Rothstein T., CD25+B-1a cells express Aicda, Frontiers in Immunology, 2017-06-20 00:00:00. (Journal). Published, 06/20/2017.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=900000081
  • Holodick NE, Rodríguez-Zhurbenko N, Hernández AM, Defining Natural Antibodies., Frontiers in immunology, 2017-01-01 00:00:00. (Journal Article). Published, 2017.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=28798747
  • Kaku H, Holodick NE, Tumang JR, Rothstein TL, CD25 + B-1a Cells Express Aicda., Frontiers in immunology, 2017-01-01 00:00:00. (Journal Article). Published, 2017.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=28676801
  • Martínez D, Pupo A, Cabrera L, Raymond J, Holodick NE, Hernández AM, Martínez D., Pupo A., Cabrera L., Raymond J., Holodick N., Hernández A., B-CD8+ T Cell Interactions in the Anti-Idiotypic Response against a Self-Antibody., Journal of immunology research, 2017-01-01 00:00:00. (Journal Article , Journal). Published, 2017.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=28491873
  • Hernandez AM, Holodick NE, Editorial: Natural Antibodies in Health and Disease., Frontiers in immunology, 2017-01-01 00:00:00. (Editorial). Published, 2017.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=29326696
  • Quách TD, Hopkins TJ, Holodick NE, Vuyyuru R, Manser T, Bayer RL, Rothstein TL, Quách T., Hopkins T., Holodick N., Vuyyuru R., Manser T., Bayer R., Rothstein T., Human B-1 and B-2 B Cells Develop from Lin-CD34+CD38lo Stem Cells., Journal of immunology (Baltimore, Md. : 1950), 2016-11-15 00:00:00. (Journal Article , Journal). Published, 11/15/2016.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=27815443
  • Olofsson PS, Steinberg BE, Sobbi R, Cox MA, Ahmed MN, Oswald M, Szekeres F, Hanes WM, Introini A, Liu SF, Holodick NE, Rothstein TL, Lövdahl C, Chavan SS, Yang H, Pavlov VA, Broliden K, Andersson U, Diamond B, Miller EJ, Arner A, Gregersen PK, Backx PH, Mak TW, Tracey KJ, Olofsson P., Steinberg B., Sobbi R., Cox M., Ahmed M., Oswald M., Szekeres F., Hanes W., Introini A., Liu S., Holodick N., Rothstein T., Lövdahl C., Chavan S., Yang H., Pavlov V., Broliden K., Andersson U., Diamond B., Miller E., Arner A., Gregersen P., Backx P., Mak T., Tracey K., Blood pressure regulation by CD4+ lymphocytes expressing choline acetyltransferase., Nature biotechnology, 2016-10-01 00:00:00. (Journal , Journal Article). Published, 10/01/2016.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=27617738
  • Holodick NE, Vizconde T, Hopkins TJ, Rothstein TL, Holodick N., Vizconde T., Hopkins T., Rothstein T., Age-Related Decline in Natural IgM Function: Diversification and Selection of the B-1a Cell Pool with Age., Journal of immunology (Baltimore, Md. : 1950), 2016-05-15 00:00:00. (Journal Article , Journal). Published, 05/15/2016.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=27183643
  • Rothstein T., Holodick N., Activation of B-1 Cells, Encyclopedia of Immunobiology, 2016-04-27 00:00:00. (Book). Published, 04/27/2016.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=900000082
  • Holodick N., Zeumer L., Rothstein T., Morel L., Expansion of B-1a cells with germline heavy chain sequence in lupus mice, Frontiers in Immunology, 2016-03-24 00:00:00. (Journal). Published, 03/24/2016.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=900000083
  • Kramer JM, Holodick NE, Vizconde TC, Raman I, Yan M, Li QZ, Gaile DP, Rothstein TL, Kramer J., Holodick N., Vizconde T., Raman I., Yan M., Li Q., Gaile D., Rothstein T., Analysis of IgM antibody production and repertoire in a mouse model of Sjögren's syndrome., Journal of leukocyte biology, 2016-02-01 00:00:00. (Journal Article , Journal). Published, 02/2016.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=26382297
  • Holodick NE, Zeumer L, Rothstein TL, Morel L, Expansion of B-1a Cells with Germline Heavy Chain Sequence in Lupus Mice., Frontiers in immunology, 2016-01-01 00:00:00. (Journal Article). Published, 2016.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=27047495
  • Rothstein TL, Herzenberg LA, Holodick NE, Ghosn E, Rothstein T., Herzenberg L., Holodick N., Ghosn E., B-1 Cell Development and Function., Annals of the New York Academy of Sciences, 2015-12-01 00:00:00. (Book Series). Published, 12/01/2015.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=26662722
  • Aziz M, Holodick NE, Rothstein TL, Wang P, Aziz M., Holodick N., Rothstein T., Wang P., The role of B-1 cells in inflammation., Immunologic research, 2015-12-01 00:00:00. (Journal Article , Review , Journal). Published, 12/01/2015.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=26427372
  • Holodick NE, Rothstein TL, Holodick N., Rothstein T., B cells in the aging immune system: time to consider B-1 cells., Annals of the New York Academy of Sciences, 2015-12-01 00:00:00. (Journal Article , Review , Journal). Published, 12/01/2015.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=26194480
  • Holodick NE, Vizconde T, Rothstein TL, Holodick N., Vizconde T., Rothstein T., B-1a cell diversity: nontemplated addition in B-1a cell Ig is determined by progenitor population and developmental location., Journal of immunology (Baltimore, Md. : 1950), 2014-03-01 00:00:00. (Journal Article , Journal). Published, 03/01/2014.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=24477911
  • Holodick NE, Vizconde T, Rothstein TL, Splenic B-1a Cells Expressing CD138 Spontaneously Secrete Large Amounts of Immunoglobulin in Naïve Mice., Frontiers in immunology, 2014-01-01 00:00:00. (Journal Article). Published, 2014.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=24734034
  • Holodick N., Vizconde T., Rothstein T., Splenic B-1a cells expressing CD138 spontaneously secrete large amounts of immunoglobulin in naïve mice, Frontiers in Immunology, 2014-01-01 00:00:00. (Journal). Published, 2014.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=900000084
  • Holodick NE, Rothstein TL, Atypical Response of B-1 Cells to BCR Ligation: A Speculative Model., Frontiers in immunology, 2013-12-16 00:00:00. (Journal Article , Review). E-published, 12/16/2013.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=24379817
  • Rothstein TL, Griffin DO, Holodick NE, Quach TD, Kaku H, Human B-1 cells take the stage., Annals of the New York Academy of Sciences, 2013-05-01 00:00:00. (Journal Article , Review). Published, 05/2013.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=23692567
  • Rothstein T., Griffin D., Holodick N., Quach T., Kaku H., Human B-1 cells take the stage, Annals of the New York Academy of Sciences, 2013-05-01 00:00:00. (Book Series). Published, 05/2013.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=900000086
  • Chen SS, Batliwalla F, Holodick NE, Yan XJ, Yancopoulos S, Croce CM, Rothstein TL, Chiorazzi N, Chen S., Batliwalla F., Holodick N., Yan X., Yancopoulos S., Croce C., Rothstein T., Chiorazzi N., Autoantigen can promote progression to a more aggressive TCL1 leukemia by selecting variants with enhanced B-cell receptor signaling., Proceedings of the National Academy of Sciences of the United States of America, 2013-04-16 00:00:00. (Journal Article , Journal). Published, 04/16/2013.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=23550156
  • Holodick N., Rothstein T., Atypical response of B-1 cells to BCR ligation: A speculative model, Frontiers in Immunology, 2013-01-01 00:00:00. (Journal). Published, 2013.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=900000085
  • Griffin DO, Quach T, Batliwalla F, Andreopoulos D, Holodick NE, Rothstein TL, Griffin D., Quach T., Batliwalla F., Andreopoulos D., Holodick N., Rothstein T., Human CD11b+ B1 cells are not monocytes: A reply to "Gene profiling of CD11b+ and CD11b- B1 cell subsets reveals potential cell sorting artifacts"., The Journal of experimental medicine, 2012-03-12 00:00:00. (Comment , Journal Article , Journal). Published, 03/12/2012.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=22412176
  • Griffin DO, Holodick NE, Rothstein TL, Griffin D., Holodick N., Rothstein T., Human B1 cells are CD3-: A reply to "A human equivalent of mouse B-1 cells?" and "The nature of circulating CD27+CD43+ B cells"., The Journal of experimental medicine, 2011-12-19 00:00:00. (Comment , Journal Article , Journal). Published, 12/19/2011.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=22184682
  • Griffin D., Holodick N., Rothstein T., Correction: Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20+CD27+CD43+CD70-, Journal of Experimental Medicine, 2011-04-11 00:00:00. (Journal). Published, 04/11/2011.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=900000088
  • Griffin D., Holodick N., Rothstein T., Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20+CD27+CD43+CD70-(The Journal of Experimental Medicine (2011), 208, 1, (67-80)), Journal of Experimental Medicine, 2011-02-14 00:00:00. (Journal). Published, 02/14/2011.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=900000089
  • Griffin DO, Holodick NE, Rothstein TL, Griffin D., Holodick N., Rothstein T., Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20+ CD27+ CD43+ CD70-., The Journal of experimental medicine, 2011-01-17 00:00:00. (Journal Article , Journal). Published, 01/17/2011.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=21220451
  • Tumang JR, Holodick NE, Vizconde TC, Kaku H, Francés R, Rothstein TL, A CD25⁻ positive population of activated B1 cells expresses LIFR and responds to LIF., Frontiers in immunology, 2011-01-01 00:00:00. (Journal Article). Published, 2011.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=22566797
  • Tumang J., Holodick N., Vizconde T., Kaku H., Francés R., Rothstein T., A CD25-positive population of activated B1 cells expresses LIFR and responds to LIF, Frontiers in Immunology, 2011-01-01 00:00:00. (Journal). Published, 2011.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=900000087
  • Holodick NE, Tumang JR, Rothstein TL, Holodick N., Tumang J., Rothstein T., Immunoglobulin secretion by B1 cells: differential intensity and IRF4-dependence of spontaneous IgM secretion by peritoneal and splenic B1 cells., European journal of immunology, 2010-11-01 00:00:00. (Journal Article , Journal). Published, 2010.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=21061433
  • Zhong X, Lau S, Bai C, Degauque N, Holodick NE, Steven SJ, Tumang J, Gao W, Rothstein TL, Zhong X., Lau S., Bai C., Degauque N., Holodick N., Steven S., Tumang J., Gao W., Rothstein T., A novel subpopulation of B-1 cells is enriched with autoreactivity in normal and lupus-prone mice., Arthritis and rheumatism, 2009-12-01 00:00:00. (Journal Article , Journal). Published, 12/2009.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=19950285
  • Holodick NE, Repetny K, Zhong X, Rothstein TL, Holodick N., Repetny K., Zhong X., Rothstein T., Adult BM generates CD5+ B1 cells containing abundant N-region additions., European journal of immunology, 2009-09-01 00:00:00. (Journal Article , Journal). Published, 09/2009.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=19714574
  • Holodick NE, Tumang JR, Rothstein TL, Holodick N., Tumang J., Rothstein T., Continual signaling is responsible for constitutive ERK phosphorylation in B-1a cells., Molecular immunology, 2009-09-01 00:00:00. (Journal Article , Journal). Published, 09/2009.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=19592097
  • Repetny KJ, Zhong X, Holodick NE, Rothstein TL, Hansen U, Repetny K., Zhong X., Holodick N., Rothstein T., Hansen U., Binding of LBP-1a to specific immunoglobulin switch regions in vivo correlates with specific repression of class switch recombination., European journal of immunology, 2009-05-01 00:00:00. (Journal Article , Journal). Published, 05/2009.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=19384868
  • Husain Z., Holodick N., Day C., Szymanski I., Alper C., Increased apoptosis of CD20+IgA+B cells is the basis for IgA deficiency: The molecular mechanism for correction in vitro by IL-10 and CD40L, Journal of Clinical Immunology, 2006-03-01 00:00:00. (Journal). Published, 03/2006.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=16758339
  • Barrington RA, Zhang M, Zhong X, Jonsson H, Holodick N, Cherukuri A, Pierce SK, Rothstein TL, Carroll MC, Barrington R., Zhang M., Zhong X., Jonsson H., Holodick N., Cherukuri A., Pierce S., Rothstein T., Carroll M., CD21/CD19 coreceptor signaling promotes B cell survival during primary immune responses., Journal of immunology (Baltimore, Md. : 1950), 2005-09-01 00:00:00. (Journal Article , Journal). Published, 09/01/2005.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=16116172